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“Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity”

Center for Biotechnology Director Dr. Clinton Rubin has co-authored a recent article published in Nature Reviews Endocrinology ““Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity”.  Abstract below, full article here.

Abstract: 

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with pharmacological interventions that are associated with poor adherence and adverse effects. Complicating efforts to improve clinical outcomes, the incidence of obesity is increasing, predisposing the population to a range of musculoskeletal complications and metabolic disorders. Pharmacological management of obesity has yet to deliver notable reductions in weight and debilitating complications are rarely avoided. By contrast, exercise shows promise as a non-invasive and non-pharmacological method of regulating both osteoporosis and obesity. The principal components of exercise — mechanical signals — promote bone and muscle anabolism while limiting formation and expansion of fat mass. Mechanical regulation of bone and marrow fat might be achieved by regulating functions of differentiated cells in the skeletal tissue while biasing lineage selection of their common progenitors — mesenchymal stem cells. An inverse relationship between adipocyte versus osteoblast fate selection from stem cells is implicated in clinical conditions such as childhood obesity and increased marrow adiposity in type 2 diabetes mellitus, as well as contributing to skeletal frailty. Understanding how exercise-induced mechanical signals can be used to improve bone quality while decreasing fat mass and metabolic dysfunction should lead to new strategies to treat chronic diseases such as osteoporosis and obesity.

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                    [post_content] => 

Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”

The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.

Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies

This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.

For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

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DATE: Wednesday, September 15, 2021
TIME: 12:00 PM EDT / 9:00AM PT

Join as AdvaMed presents  “Advancing Public Health with Wearables: Strategic Development of IoMT Biosensing Lifestyle Devices” with MIDI Medical Device Development Corp. and Valencell, Inc. This webinar is presented by Christopher Montalbano, CEO, MIDI Medical Device Development Corp., and Ryan Kraudel, Vice President, Marketing, Valencell, Inc., this webinar will examine the way in which wearables advance public health when a strategic device development approach is utilized to integrate and harmonize: Lifestyle, IoMT, Biosensing, and Physiological Sensing.

In this AdvaMed Event, MIDI & Valencell will cover:
• Understand how wearable IoMT devices utilizing Bio-Sensors and Physiological Sensors translate into enhanced healthcare and wellness lifestyles.
• Learn how to optimize the selection of sensor (or sensor cluster) through a proven 4-Step approach of: User Experience Monitoring, Body Assessments, Key Body Metric Capture and Sensor Selection.
• Learn the 3-Step Innovation Roadmap™ for optimized wearable device development including: Discovery Research™, MVP R&D and AGILE Commercialization under ISO-13485.
• Review of Case Studies that demonstrate implementation of these innovation principles yielding advanced wearable IoMT healthcare sensing devices.

REGISTER HERE

[post_title] => Webinar: Advancing Public Health with Wearables: Strategic Development of IoMT Biosensing Lifestyle Devices - September 15th [post_excerpt] => On September 15 join as  MIDI Medical Device Development Corp. AdvaMed, and Valencell, Inc. present  “Advancing Public Health with Wearables: Strategic Development of IoMT Biosensing Lifestyle Devices” [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => webinar-advancing-public-health-with-wearables-strategic-development-of-iomt-biosensing-lifestyle-devices-september-15th [to_ping] => [pinged] => [post_modified] => 2021-09-20 16:02:48 [post_modified_gmt] => 2021-09-20 16:02:48 [post_content_filtered] => [post_parent] => 0 [guid] => https://centerforbiotechnology.org/?p=3814 [menu_order] => 38 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 2417 [post_author] => 3 [post_date] => 2016-10-07 13:15:28 [post_date_gmt] => 2016-10-07 13:15:28 [post_content] => Vitatex, a Stony Brook-based biotechnology company located in the Long Island High Technology Incubator, has announced that it was awarded an SBIR Phase I/II Fast Track contract in September 2015 from the National Cancer Institute (NCI) for its Vita-Cap™ CTC Capture and Preservation tubes. A modification to exercise the option for a two-year SBIR Phase II of the contract was executed on June 8, 2016. Vitatex Inc. provides proprietary invasive circulating tumor cell (iCTC) enrichment technology and products to develop revolutionary cancer genetic and cell tests. These "liquid biopsies" focus on next generation sequencing (NGS) detection, gene expression profiling and flow cytometry and have recently been adopted by the clinical laboratory community to characterize cancer cells and/or their RNA/DNA in blood samples non-invasively and serially, and to acquire genetic alternations and drug resistance information, which have the potential to replace tests run on surgical biopsies. Clinical metastasis of solid tumors is linked to blood-borne dissemination of viable tumor cells in the circulation and clinical instrumentation is now available to isolate, enumerate, culture, generate metastatic mouse models and perform molecular analyses on these circulating tumor cells (CTCs). However, CTCs are fragile and tend to degrade within a few days when collected in standard blood collection tubes. "The functional CTC preparation tube is designed to collect, enrich and preserve the viability/functionality of cancer cells in blood all within a closed system" said Wen-Tien Chen, PhD., Chief Scientific Officer of Vitatex. "The goal is to define conditions of Vitatex CTC preparation tubes for capturing and preserving cancer cells in the blood of patients with breast, ovarian and other types for up to 96 hours of transit." Specific terms of the contract were not disclosed. [post_title] => Vitatex Awarded NCI Contract [post_excerpt] => Stony Brook biotech company, Vitatex, has announced it was awarded an NCI Contract for Circulating Tumor Cell (CTC) Capture and Preservation Tubes. [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vitatex-awarded-nci-contract [to_ping] => [pinged] => [post_modified] => 2016-12-06 15:12:47 [post_modified_gmt] => 2016-12-06 15:12:47 [post_content_filtered] => [post_parent] => 0 [guid] => http://centerforbiotechnology.org/?p=2417 [menu_order] => 164 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 3 [current_post] => -1 [before_loop] => 1 [in_the_loop] => [post] => WP_Post Object ( [ID] => 4285 [post_author] => 4 [post_date] => 2023-09-11 12:13:16 [post_date_gmt] => 2023-09-11 16:13:16 [post_content] =>

Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”

The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.

Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies

This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.

For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

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“Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing” 10/12/23

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Webinar: Advancing Public Health with Wearables: Strategic Development of IoMT Biosensing Lifestyle Devices – September 15th

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Vitatex Awarded NCI Contract

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