Client News: First In-Human Clinical Trial Targeting CD4 Protein for Aggressive T-cell Leukemia and Lymphoma to be Launched | Center for Biotechnology – Stony Brook University

Close

Donate

Whether your personal interests are in supporting innovation, bringing lifesaving biomedical products to patients, training the next generation of biomedical leaders or fueling our economy, the Center for Biotechnology provides a vehicle to accomplish great things. Things that matter. Things that change, and save, lives. Your involvement is an essential part of our future. Please consider a gift to the Center for Biotechnology which will help fuel innovation by ensuring that lifesaving technologies make it out of research labs and into the hands of patients. Give to the Center for Biotechnology online through the Stony Brook Foundation. Contributions can be made to our Fund for Excellence. More information about donating through the Stony Brook Foundation can be found here.

Back to News & Events

Client News: First In-Human Clinical Trial Targeting CD4 Protein for Aggressive T-cell Leukemia and Lymphoma to be Launched

August 13, 2018

Stony Brook University, iCell Gene Therapeutics and University of Louisville collaborate to offer a new CAR T immunotherapy to treat patients.

Stony Brook University, iCell Gene Therapeutics, and the University of Louisville, have received Food and Drug Administration (FDA) clearance for an Investigational New Drug (IND) for the treatment of relapsed and refractory T-cell leukemia and lymphoma. The approach is the first to use chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR). Together, Stony Brook University, the University of Louisville, and iCell Gene Therapeutics expect the first in-human Phase I clinical trial to begin accruing patients before the end of 2018.

“We are excited to partner with the University of Louisville and iCell Gene Therapeutics to offer this innovative first-in-human CAR T cell immunotherapy clinical trial for patients who are suffering from these extremely difficult to treat T cell lymphomas and leukemias,” said Huda Salman, MD, Principal Investigator for the IND and an oncologist at Stony Brook University Cancer Center. “CD4CAR T cells may prove to be a promising and novel therapy in this setting.”

“The development of this trial using CD4 as a target is the first of what we expect to be many CAR T-based clinical trials available to our patients over time,” said Yusuf Hannun, MD, Director of the Stony Brook University Cancer Center. “The pending trial is an example of the type of bench-to-bedside research that is building up at Stony Brook due to the growing expertise and collaborative research environment we are creating and new opportunities that will emerge upon the opening of our Medical and Research Translation (MART) Building.”

William Tse, MD, FACP, Chief of the Blood and Marrow Transplantation at the University of Louisville School of Medicine, is the Co-PI of the CD4CAR clinical trial at University of Louisville site.

Related Stories

WP_Query Object
(
    [query] => Array
        (
            [post_type] => post
            [posts_per_page] => 3
            [post_status] => publish
            [orderby] => rand
        )

    [query_vars] => Array
        (
            [post_type] => post
            [posts_per_page] => 3
            [post_status] => publish
            [orderby] => rand
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [paged] => 0
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [order] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => 
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts 
					WHERE 1=1  AND wp_posts.post_type = 'post' AND ((wp_posts.post_status = 'publish'))
					
					ORDER BY RAND()
					LIMIT 0, 3
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 4285
                    [post_author] => 4
                    [post_date] => 2023-09-11 12:13:16
                    [post_date_gmt] => 2023-09-11 16:13:16
                    [post_content] => 
Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”



The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.



Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies



This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.



For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

                    [post_title] => "Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing" 10/12/23
                    [post_excerpt] => Join Stony Brook University’s Intellectual Property Partners on  October 12th for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”
                    [post_status] => publish
                    [comment_status] => open
                    [ping_status] => open
                    [post_password] => 
                    [post_name] => bring-your-new-technology-innovations-to-life-through-prototyping-and-manufacturing-10-12-23
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-11-15 11:24:35
                    [post_modified_gmt] => 2023-11-15 16:24:35
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://centerforbiotechnology.org/?p=4285
                    [menu_order] => 0
                    [post_type] => post
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 1208
                    [post_author] => 3
                    [post_date] => 2014-07-17 13:24:02
                    [post_date_gmt] => 2014-07-17 13:24:02
                    [post_content] => Israel Kleinberg, DDS,PhD, DSc, Distinguished Professor in the Depart of Oral Biology and Pathology, at Stony Brook University, and his commercial partner Ortek Therapeutics, have launched BasicBites®, a chewable candy that is actually beneficial for your teeth. BasicBites? are designed to mimic saliva's profound and natural benefits. The science behind BasicBites, AlkaGen Technology™, was developed in part with support from the Center for Biotechnology. Read the full press release and more about the launch. More information on the product can be found on the BasicBites? website at www.basicbites.com.
                    [post_title] => BasicBites™, Candy for Dental Health Launched
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => open
                    [ping_status] => open
                    [post_password] => 
                    [post_name] => basicbites-candy-for-dental-health-launched
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-03-21 21:56:53
                    [post_modified_gmt] => 2016-03-21 21:56:53
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://centerforbiotechnology.org/new/?p=1208
                    [menu_order] => 224
                    [post_type] => post
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3083
                    [post_author] => 3
                    [post_date] => 2018-11-16 14:26:57
                    [post_date_gmt] => 2018-11-16 14:26:57
                    [post_content] => Update courtesy of BBC Entrepreneurial Training and Consulting

NIH is strongly encouraging small businesses to contact the appropriate Institute or Center early in their application planning to ensure their technology is a priority for the Institute/Center.

An updated SBIR/STTR Application Guide with additional instructions for SBIR Direct Phase II application preparation and submission will be posted by November 26, 2018. The following sections of each FOA are changed:

Part 2, Section I. Funding Opportunity Description The following has been added at the end of the section for each FOA:

PA-18-573 The following Components will not accept an SBIR Direct-to-Phase II submission:
- National Institute of Nursing Research (NINR)
- National Center for Complementary and Integrative Health (NCCIH)

PA-18-574 The following Components will not accept an SBIR Direct-to-Phase II submission:
- National Institute of Environmental Health Sciences (NIEHS )
- National Institute of Nursing Research (NINR)
- National Center for Complementary and Integrative Health (NCCIH)
- Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
- Centers for Disease Control and Prevention (CDC) (All Components of CDC)
- U.S. Food and Drug Administration (FDA) (All Components of FDA)

Part 2, Section II. Award Information for both PA-18-573 and PA-18-574. Application types now allowed are:
- New (Phase I, Fast-Track)
- New (Direct Phase II)
- Renewal (Phase II)
- Resubmission (all phases)
- Phase IIB Competing Renewal (Phase IIB)
- Revision

The OER Glossary and the SF424 (R&R) SBIR/STTR Application Guide provide details on these application types.
                    [post_title] => Important SBIR/STTR Information Update from NIH
                    [post_excerpt] => An updated SBIR/STTR Application Guide with additional instructions for SBIR Direct Phase II application preparation and submission will be posted by November 26, 2018. 
                    [post_status] => publish
                    [comment_status] => open
                    [ping_status] => open
                    [post_password] => 
                    [post_name] => important-sbirsttr-information-update-from-nih
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2018-11-16 14:26:57
                    [post_modified_gmt] => 2018-11-16 14:26:57
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://centerforbiotechnology.org/?p=3083
                    [menu_order] => 110
                    [post_type] => post
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 2050
                    [post_author] => 3
                    [post_date] => 2015-12-07 19:47:05
                    [post_date_gmt] => 2015-12-07 19:47:05
                    [post_content] => Stony Brook-based technology startup, QB Sonic, is the local winner of the federal Small Business Administration’s InnovateHER competition, a national contest for companies seeking to improve the lives of women and families. The company will advance to the semifinal round. Read more about the company and the competition here.
                    [post_title] => QB Sonic Wins SBA InnovateHER Competition
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => open
                    [ping_status] => open
                    [post_password] => 
                    [post_name] => qb-sonic-wins-sba-innovateher-competition
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-03-29 19:51:04
                    [post_modified_gmt] => 2016-03-29 19:51:04
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://centerforbiotechnology.org/?p=2050
                    [menu_order] => 196
                    [post_type] => post
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 4
    [current_post] => -1
    [before_loop] => 1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 4285
            [post_author] => 4
            [post_date] => 2023-09-11 12:13:16
            [post_date_gmt] => 2023-09-11 16:13:16
            [post_content] => 
Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”



The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.



Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies



This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.



For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

            [post_title] => "Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing" 10/12/23
            [post_excerpt] => Join Stony Brook University’s Intellectual Property Partners on  October 12th for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”
            [post_status] => publish
            [comment_status] => open
            [ping_status] => open
            [post_password] => 
            [post_name] => bring-your-new-technology-innovations-to-life-through-prototyping-and-manufacturing-10-12-23
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2023-11-15 11:24:35
            [post_modified_gmt] => 2023-11-15 16:24:35
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://centerforbiotechnology.org/?p=4285
            [menu_order] => 0
            [post_type] => post
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 249
    [max_num_pages] => 83
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 325c4f9f1aebaa5ec90666fa54175ba0
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

“Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing” 10/12/23

September 11, 2023

More Information

BasicBites™, Candy for Dental Health Launched

July 17, 2014

More Information

Important SBIR/STTR Information Update from NIH

November 16, 2018

More Information

QB Sonic Wins SBA InnovateHER Competition

December 7, 2015

More Information