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“Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity”

Center for Biotechnology Director Dr. Clinton Rubin has co-authored a recent article published in Nature Reviews Endocrinology ““Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity”.  Abstract below, full article here.

Abstract: 

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with pharmacological interventions that are associated with poor adherence and adverse effects. Complicating efforts to improve clinical outcomes, the incidence of obesity is increasing, predisposing the population to a range of musculoskeletal complications and metabolic disorders. Pharmacological management of obesity has yet to deliver notable reductions in weight and debilitating complications are rarely avoided. By contrast, exercise shows promise as a non-invasive and non-pharmacological method of regulating both osteoporosis and obesity. The principal components of exercise — mechanical signals — promote bone and muscle anabolism while limiting formation and expansion of fat mass. Mechanical regulation of bone and marrow fat might be achieved by regulating functions of differentiated cells in the skeletal tissue while biasing lineage selection of their common progenitors — mesenchymal stem cells. An inverse relationship between adipocyte versus osteoblast fate selection from stem cells is implicated in clinical conditions such as childhood obesity and increased marrow adiposity in type 2 diabetes mellitus, as well as contributing to skeletal frailty. Understanding how exercise-induced mechanical signals can be used to improve bone quality while decreasing fat mass and metabolic dysfunction should lead to new strategies to treat chronic diseases such as osteoporosis and obesity.

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                    [post_content] => 

Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”

The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.

Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies

This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.

For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

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The Center for Biotechnology has announced a Call for Proposals for our 2022 Applied Research and Development (ARAD) Program. The ARAD program provides matching funds on a competitive basis to support collaborations between Stony Brook University faculty and NY State corporate partners in all areas of medical biotechnology.

These areas include research technologies, diagnostics, therapeutics and medical devices. The primary interest is in supporting development of technologies that will help companies hit commercially relevant milestones, and that have the potential to positively impact the New York State economy.

2022 Proposal Submission:

The deadline for receipt of applications is April 15, 2022, 5pm. No exceptions will be made. Applications are accepted and considered on a competitive basis and are subject to the availability of funds. Approval from the Research Foundation Sponsored Programs is not required prior to submission, but will be required if the project is selected for funding. All applications require a letter-of-support from a senior executive of the company confirming their corporate residency in New York State and financial commitment to match-fund the project. Further details are found within the forms pages. A single PDF version of the proposal and letter of support should be submitted to Center for Biotechnology at center_for_biotechnology@stonybrook.edu.

ARAD Program Forms:
Call for Applications & Guidelines
Application Form
Budget Forms

[post_title] => Call for Proposals: Applied Research and Development Program [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => arad2022 [to_ping] => [pinged] => [post_modified] => 2022-12-13 17:05:39 [post_modified_gmt] => 2022-12-13 17:05:39 [post_content_filtered] => [post_parent] => 0 [guid] => https://centerforbiotechnology.org/?p=3880 [menu_order] => 26 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 3055 [post_author] => 3 [post_date] => 2018-09-04 13:33:40 [post_date_gmt] => 2018-09-04 13:33:40 [post_content] => Cold Spring Harbor Laboratory’s Alex Vaughan was awarded the 2018 Alexandria LaunchLabs Seed Capital Prize for the CSHL spinoff company MapNeuro Inc. during the NYC Life Science Innovation Showcase, held in New York City on June 14, 2018. Valued at $100,000, the prize, meant to fund early-stage development companies, includes a scholarship to Alexandria LaunchLabs, a cash award, and an investment from the Alexandria Seed Capital Platform, an innovative funding model catalyzing seed-stage life science investment. MapNeuro Inc. commercializes “molecular connectomics” technology developed in the laboratory of CSHL Professor Anthony Zador. MapNeuro uses this platform to understand brain-wide patterns of neuronal connectivity, and is specifically targeting neurodegenerative diseases such as Parkinson’s Disease and Alzheimer’s Disease. Read the full article here. [post_title] => LIBH Innovator Awarded Alexandria LaunchLabs Seed Capital Prize [post_excerpt] => CSHL spin-out MapNeuro Inc. was awarded the 2018 Alexandria LaunchLabs Seed Capital Prize during the NYC Life Science Innovation Showcase in June 2018. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => libh-innovator-awarded-alexandria-launchlabs-seed-capital-prize [to_ping] => [pinged] => [post_modified] => 2018-09-04 13:46:01 [post_modified_gmt] => 2018-09-04 13:46:01 [post_content_filtered] => [post_parent] => 0 [guid] => http://centerforbiotechnology.org/?p=3055 [menu_order] => 112 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 1337 [post_author] => 3 [post_date] => 2014-10-07 16:44:23 [post_date_gmt] => 2014-10-07 16:44:23 [post_content] => Just released - the Center for Biotechnology's Summer/Fall 2014 News Update recapping the latest news and upcoming events, including spotlighting client company Intensity Therapeutics. Read it here. [post_title] => Center for Biotechnology Summer/Fall 2014 News Update [post_excerpt] => [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => center-for-biotechnology-summerfall-2014-news-update [to_ping] => [pinged] => [post_modified] => 2015-01-28 16:57:03 [post_modified_gmt] => 2015-01-28 16:57:03 [post_content_filtered] => [post_parent] => 0 [guid] => http://centerforbiotechnology.org/new/?p=1337 [menu_order] => 217 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 4 [current_post] => -1 [before_loop] => 1 [in_the_loop] => [post] => WP_Post Object ( [ID] => 4285 [post_author] => 4 [post_date] => 2023-09-11 12:13:16 [post_date_gmt] => 2023-09-11 16:13:16 [post_content] =>

Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”

The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.

Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies

This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.

For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

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“Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing” 10/12/23

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