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“Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity”

Center for Biotechnology Director Dr. Clinton Rubin has co-authored a recent article published in Nature Reviews Endocrinology ““Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity”.  Abstract below, full article here.

Abstract: 

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with pharmacological interventions that are associated with poor adherence and adverse effects. Complicating efforts to improve clinical outcomes, the incidence of obesity is increasing, predisposing the population to a range of musculoskeletal complications and metabolic disorders. Pharmacological management of obesity has yet to deliver notable reductions in weight and debilitating complications are rarely avoided. By contrast, exercise shows promise as a non-invasive and non-pharmacological method of regulating both osteoporosis and obesity. The principal components of exercise — mechanical signals — promote bone and muscle anabolism while limiting formation and expansion of fat mass. Mechanical regulation of bone and marrow fat might be achieved by regulating functions of differentiated cells in the skeletal tissue while biasing lineage selection of their common progenitors — mesenchymal stem cells. An inverse relationship between adipocyte versus osteoblast fate selection from stem cells is implicated in clinical conditions such as childhood obesity and increased marrow adiposity in type 2 diabetes mellitus, as well as contributing to skeletal frailty. Understanding how exercise-induced mechanical signals can be used to improve bone quality while decreasing fat mass and metabolic dysfunction should lead to new strategies to treat chronic diseases such as osteoporosis and obesity.

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CFB Client, IAMBIC has been awarded approximately $1M in grant funding from the National Science Foundation Small Business Innovation Research program. IAMBIC is an innovative shoe company disrupting the centuries-old footwear industry with their sizeless, precision-fit footwear driven by proprietary AI algorithms. This substantial funding from NSF enables IAMBIC to scale its cutting-edge precision-fit shoe design and manufacturing.

The Center for Biotechnology and its accelerator programs have been instrumental in assisting IAMBIC with their SBIR pursuits and commercialization development.

Read more about IAMBIC and their recent funding here.

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Join our team! The Center for Biotechnology is recruiting an Assistant Director for Technology and Business Development. The Asst. Director for Technology and Business Development will develop and help implement milestone driven commercialization strategies, and provide oversight to Commercialization Associates who have primary responsibility for conducting due diligence to guide and support Center for Biotechnology/LIBH “investments".

The incumbent will serve as the primary contact with internal and external parties on issues related to research, technology development and commercialization, and foster new collaborative relationships leading to sponsored research agreements and possible strategic alliances with external partners including bioscience companies and investors. 

Read the full position description and apply via the “stony Brook at work” website: https://stonybrooku.taleo.net/careersection/jobdetail.ftl?job=2101841&lang=en

Questions? Contact Anne DePietri (annette.depietri@stonybrook.edu) at the Center for Biotechnology.

[post_title] => CFB Career Opportunity: Assistant Director for Technology and Business Development [post_excerpt] => The CFB is recruiting an Assistant Director for Technology and Business Development. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => cfb-career-opportunity-assistant-director-for-technology-and-business-development [to_ping] => [pinged] => [post_modified] => 2022-08-22 13:09:32 [post_modified_gmt] => 2022-08-22 13:09:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://centerforbiotechnology.org/?p=3794 [menu_order] => 42 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 3404 [post_author] => 3 [post_date] => 2020-01-02 16:35:15 [post_date_gmt] => 2020-01-02 16:35:15 [post_content] => ASPR/BARDA is issuing a Request for Information (RFI) to assist in understanding the developmental landscape of next generation blood products that could be used to treat mechanical trauma and bleeding associated with acute radiation syndrome and potentially supplement the blood supply in the wake of a mass casualty event such as a nuclear or radiological scenario. BARDA intends to use responses to this RFI for planning potential future acquisitions. BARDA seeks pertinent marketplace data to strengthen BARDA’s understanding of the current and future marketplace as well as enhance its ability to obtain quality services and products economically, and to efficiently and lawfully establish potential vendor source files and listings. BARDA will not award any potential contracts under this notice. This is strictly for market research. Link to the RFI: https://bit.ly/2LSjOEc . [post_title] => BARDA RFI: Next Generation Blood Products [post_excerpt] => ASPR/BARDA is issuing a Request for Information (RFI) to assist in understanding the developmental landscape of next generation blood products. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => barda-rfi-next-generation-blood-products [to_ping] => [pinged] => [post_modified] => 2020-01-31 20:01:41 [post_modified_gmt] => 2020-01-31 20:01:41 [post_content_filtered] => [post_parent] => 0 [guid] => https://centerforbiotechnology.org/?p=3404 [menu_order] => 81 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 3131 [post_author] => 4 [post_date] => 2019-01-24 15:24:44 [post_date_gmt] => 2019-01-24 15:24:44 [post_content] => BARDA’s DRIVe is pleased to announce the expansion of its market research effort to identify potential partners and capture feedback to support its newest novel public-private partnership, DRIVe Ventures. DRIVe Ventures will work with corporate venture capital partners to invest in promising products, driving them to the marketplace to transform and enhance national health security. BARDA DRIVe seeks feedback on a potential new novel public-private partnership that leverages venture capital practices and methods to disrupt the way BARDA invests in health security innovation. Learn more.   [post_title] => Request for Information: BARDA DRIVe Ventures [post_excerpt] => BARDA DRIVe wants to hear from the venture capital community – looking for feedback to support its newest novel public-private partnership, DRIVe Ventures. [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => request-for-information-barda-drive-ventures [to_ping] => [pinged] => [post_modified] => 2019-04-09 14:41:07 [post_modified_gmt] => 2019-04-09 14:41:07 [post_content_filtered] => [post_parent] => 0 [guid] => http://centerforbiotechnology.org/?p=3131 [menu_order] => 104 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 4 [current_post] => -1 [before_loop] => 1 [in_the_loop] => [post] => WP_Post Object ( [ID] => 4439 [post_author] => 3 [post_date] => 2024-07-30 15:29:07 [post_date_gmt] => 2024-07-30 19:29:07 [post_content] =>

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The Center for Biotechnology and its accelerator programs have been instrumental in assisting IAMBIC with their SBIR pursuits and commercialization development.

Read more about IAMBIC and their recent funding here.

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CFB Client IAMBIC Receives $1 Million NSF SBIR Phase II Grant

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