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Client News: First In-Human Clinical Trial Targeting CD4 Protein for Aggressive T-cell Leukemia and Lymphoma to be Launched

Stony Brook University, iCell Gene Therapeutics and University of Louisville collaborate to offer a new CAR T immunotherapy to treat patients.

Stony Brook University, iCell Gene Therapeutics, and the University of Louisville, have received Food and Drug Administration (FDA) clearance for an Investigational New Drug (IND) for the treatment of relapsed and refractory T-cell leukemia and lymphoma. The approach is the first to use chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR). Together, Stony Brook University, the University of Louisville, and iCell Gene Therapeutics expect the first in-human Phase I clinical trial to begin accruing patients before the end of 2018.

“We are excited to partner with the University of Louisville and iCell Gene Therapeutics to offer this innovative first-in-human CAR T cell immunotherapy clinical trial for patients who are suffering from these extremely difficult to treat T cell lymphomas and leukemias,” said Huda Salman, MD, Principal Investigator for the IND and an oncologist at Stony Brook University Cancer Center. “CD4CAR T cells may prove to be a promising and novel therapy in this setting.”

“The development of this trial using CD4 as a target is the first of what we expect to be many CAR T-based clinical trials available to our patients over time,” said Yusuf Hannun, MD, Director of the Stony Brook University Cancer Center. “The pending trial is an example of the type of bench-to-bedside research that is building up at Stony Brook due to the growing expertise and collaborative research environment we are creating and new opportunities that will emerge upon the opening of our Medical and Research Translation (MART) Building.”

William Tse, MD, FACP, Chief of the Blood and Marrow Transplantation at the University of Louisville School of Medicine, is the Co-PI of the CD4CAR clinical trial at University of Louisville site.

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                    [post_content] => 

Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”

The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.

Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies

This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.

For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

[post_title] => "Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing" 10/12/23 [post_excerpt] => Join Stony Brook University’s Intellectual Property Partners on October 12th for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.” [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => bring-your-new-technology-innovations-to-life-through-prototyping-and-manufacturing-10-12-23 [to_ping] => [pinged] => [post_modified] => 2023-11-15 11:24:35 [post_modified_gmt] => 2023-11-15 16:24:35 [post_content_filtered] => [post_parent] => 0 [guid] => https://centerforbiotechnology.org/?p=4285 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [1] => WP_Post Object ( [ID] => 3880 [post_author] => 4 [post_date] => 2022-03-15 14:30:41 [post_date_gmt] => 2022-03-15 14:30:41 [post_content] =>

The Center for Biotechnology has announced a Call for Proposals for our 2022 Applied Research and Development (ARAD) Program. The ARAD program provides matching funds on a competitive basis to support collaborations between Stony Brook University faculty and NY State corporate partners in all areas of medical biotechnology.

These areas include research technologies, diagnostics, therapeutics and medical devices. The primary interest is in supporting development of technologies that will help companies hit commercially relevant milestones, and that have the potential to positively impact the New York State economy.

2022 Proposal Submission:

The deadline for receipt of applications is April 15, 2022, 5pm. No exceptions will be made. Applications are accepted and considered on a competitive basis and are subject to the availability of funds. Approval from the Research Foundation Sponsored Programs is not required prior to submission, but will be required if the project is selected for funding. All applications require a letter-of-support from a senior executive of the company confirming their corporate residency in New York State and financial commitment to match-fund the project. Further details are found within the forms pages. A single PDF version of the proposal and letter of support should be submitted to Center for Biotechnology at center_for_biotechnology@stonybrook.edu.

ARAD Program Forms:
Call for Applications & Guidelines
Application Form
Budget Forms

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To accelerate the development of the next generation of masks, BARDA and NIOSH have partnered to launch the Mask Innovation Challenge: Building Tomorrow’s Mask. The Mask Innovation Challenge aims to improve the comfort, utility, and protective capabilities of available community masks that are worn during day-to-day activities when physical distancing is not possible. This competition is designed to support the development of mask designs that meet predefined performance standards, while providing increased comfort and durability to the average consumer.

Can you help build a better mask – one that people are interested in wearing? You will have helped solved one of the biggest problems of the day! The mask design innovation challenge puts up a $500,000 prize purse for new mask designs that overcome the common reasons people don’t wear masks in the current pandemic. Phase 1 is design, due 5 p.m. April 21, 2021; phase 2 is testing of prototypes by NIOSH scientists and partner labs. Learn more at drive.hhs.gov/mask_challenge.html and then see Challenge.gov for the rules, criteria, timelines and how to submit.

Mask Innovation Challenge Event 4/15

Don't miss the Mask Innovation Challenge event at the Venture Café at UCSC on Thursday, April 15, 2021: "Why we need to innovate on the non-medical grade face mask" from 3-4pm EDT. HHS’s Biomedical Advanced Research and Development Authority (BARDA) will discuss comfort, utility, and protective factor of current non-medical grade face masks as well as opportunities to innovate on these designs.

Event link*: https://venturecafephiladelphia.org/event/why-we-need-to-innovate-on-the-non-medical-grade-face-mask/

8this link can be used to access the event on the day of the talk, no registration required)

[post_title] => BARDA: Mask Innovation Challenge [post_excerpt] => Can you help build a better mask – one that people are interested in wearing? The mask design innovation challenge puts up a $500,000 prize purse for new mask designs that overcome the common reasons people don’t wear masks in the current pandemic. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => barda-mask-innovation-challenge [to_ping] => [pinged] => [post_modified] => 2021-09-20 16:13:51 [post_modified_gmt] => 2021-09-20 16:13:51 [post_content_filtered] => [post_parent] => 0 [guid] => https://centerforbiotechnology.org/?p=3750 [menu_order] => 48 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 2675 [post_author] => 3 [post_date] => 2017-04-26 14:28:05 [post_date_gmt] => 2017-04-26 14:28:05 [post_content] => The Center for Biotechnology is seeking one or more qualified and motivated high school /undergrad students interested in learning about and supporting technology development and commercialization of new biomedical innovations on behalf of the Long Island Bioscience Hub (LIBH). The LIBH is a National Institutes of Health-designated Research, Evaluation, and Commercialization Hub (REACH), one of only three such centers in the country. The LIBH supports the development and commercialization activities of its partner institutions including Stony Brook University, Cold Spring Harbor Laboratory, and Brookhaven National Laboratory. Candidates for the Fellowship will have completed their sophomore year in high school through junior year in undergraduate studies. Candidates should have a GPA of no less than a 3.0, and have an interest in exploring careers in a biomedical field. Interested candidates should send a one-page statement of interest detailing their academic accomplishments and describing what they would like to gain from the Fellowship experience, along with a transcript to: Kristina Duryea kristina.duryea@stonybrook.edu. Selection Process: Deadline for application materials is May 1 – June 2, 2017. Additional admissions procedures (including interviews, by telephone or in person) may be required. Notification: Applicants will generally be notified by June 9, 2017. One-two applicants are expected to be selected. [post_title] => Commercialization Fellowship for High School Students & Undergrads [post_excerpt] => [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => commercialization-internship-2017 [to_ping] => [pinged] => [post_modified] => 2017-04-26 14:28:05 [post_modified_gmt] => 2017-04-26 14:28:05 [post_content_filtered] => [post_parent] => 0 [guid] => http://centerforbiotechnology.org/?p=2675 [menu_order] => 149 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 4 [current_post] => -1 [before_loop] => 1 [in_the_loop] => [post] => WP_Post Object ( [ID] => 4285 [post_author] => 4 [post_date] => 2023-09-11 12:13:16 [post_date_gmt] => 2023-09-11 16:13:16 [post_content] =>

Join Stony Brook University’s Intellectual Property Partners on Thursday, October 12, from 4:30 pm to 6 pm at the Charles B. Wang Center at Stony Brook University for the panel discussion titled “Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing.”

The event will be hosted by Intellectual Property Partners (IPP), the SBU Chapter of the National Academy of Inventors (NAI), and the Manufacturing and Technology Resource Consortium (MTRC) and will be followed by a networking cocktail reception from 6 pm to 7 pm.

Moderated by Dr. James Hayward, President, CEO and Chairman of Applied DNA Sciences, panelists include:
– Adrian Howansky, PhD, Clinical Medical Physicist, Department of Radiology, Stony Brook University Hospital
– Doreen Swift, Senior Director, Embedded Software Engineering, IPS
– Michael R. Bielski, President, DevTech Partners
– Nariman Boyle, MD, Director, Ophthalmic Plastic Orbit and Reconstructive Surgery, Department of Ophthalmology, Renaissance School of Medicine, Stony Brook University
– Paul Schwartz, Director, Advanced Propulsion Technologies

This event is free and open to Stony Brook University attendees. Space is limited and registration is required. Register here to secure your spot.

For more information visit: https://www.stonybrook.edu/commcms/ipp/Events/Manufacturing.php

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“Bring Your New Technology Innovations to Life Through Prototyping and Manufacturing” 10/12/23

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Commercialization Fellowship for High School Students & Undergrads

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